Effects of caffeic acid phenethyl ester in wnt/?-catenin signaling pathway on human neuroglioma
- VernacularTitle:CAPE对神经胶质瘤生长抑制作用研究
- Author:
Chuan GUO
- Publication Type:Journal Article
- Keywords:
?-catenin;
Caffeic acid phenethyl ester(CAPE);
Neuroglioma
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The therapic effect of caffeic acid phenethyl ester(CAPE) in neuroglioma was to be investigated in this article.Methods:Athymic mouse model was constructed for therapic observation when tumor was treated by CAPE in vivo.Then Real-time PCR was employed to detected the expressing level of c-myc and ?-catenin genes in Wnt/?-catenin signaling pathway when U251 cells were treated by CAPE.Results:CAPE could inhibit the growth of neuroglioma in athymic mouse through drug oral application.The mRNA and protein expression of ?-catenin were inhibited.Furthermore,c-myc gene,which was the downstream of?-catenin gene,was also down-regulated after the drug treatment.Conclusion:The expressing level of ?-catenin and c-myc genes were down-regulated after CAPE treatment, by which the growth of neuroglioma could be inhibited.
