Effects of Trail combined with chenotherapeutics on proliferation and apoptosis of HNE-1 cell line
- VernacularTitle:化疗药物联合TRAIL对鼻咽癌细胞株增殖抑制的实验研究
- Author:
Xiaoyan YU
- Publication Type:Journal Article
- Keywords:
TRAIL;
DDP;
5-FU;
HNE-1 cell line
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of different concentrations of TRAIL and chemotherapeutic drugs(5-FU,DDP) on proliferation and apoptosis of HNE-1 cell lines ,both singlely and jointly.Methods:MTT was used to detect the inhibition rate.FCM was used to detect the apoptosis rate of cell.Results:The inhibition rate and apoptosis rate of combination use of TRAIL and 5-FU,DDP were significantly increased,compared with those of single use of TRAIL.Conclusion:The inhibition of proliferation and apoptosis of HNE-1 cell line can be induced by TRAIL,and the effects were higher by TRAIL combined with 5-FU and DDP.
