Preparation and dissolution of Wurenchun Dispersible Tablet
- VernacularTitle:五仁醇分散片的制备工艺研究及体外溶出度试验
- Author:
Yuhong LIU
;
Jinhai YI
;
Zhifang HUANG
;
Yan CHEN
;
Yunhua LIU
- Publication Type:Journal Article
- Keywords:
Wurenchun Dispersible Tablets;
deoxyschisandrin;
dissolution
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To prepare Wurenchun Dispersible Tablet(Fructus schisandrae Chinensis)and investigate the dissolution of it.METHODS:The optimal formulation of Wurenchun Dispersible Tablets was established by the single factor experiments.The dissolution of deoxyschisandrin from Wurenchun Dispersible Tablets was determined by HPLC.RESULTS:Wurenchun Dispersible Tablets prepared by the mixture of 50 g extraction and 125 g CaHPO_4 plus excipent(MCC∶CMS-Na 3∶1)could disintegrate and disperse well within 3 min in(20?1)℃ water.The dissolution of deoxyschisandrin from Wurenchun Dispersible Tablets was higher than 80% in 15 min.CONCLUSION:Wurenchun Dispersible Tablets were stable,dissolved fast and completely.The preparation could promote the dissolution of total lignans.
