Absorption mechanism of aesculin across Caco-2 monolayer mode
- VernacularTitle:秦皮甲素在Caco-2细胞模型中吸收机制的研究
- Author:
Shijia LIU
;
Wenzheng JU
;
Ningning XIONG
;
Zhiyuan CHEN
;
Hengshan TAN
- Publication Type:Journal Article
- Keywords:
aesculin;
Caco-2 cell model;
HPLC;
intestinal absorption;
transport
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To research the absorption mechanism of aesculin across Caco-2 monolayer model.METHODS:The Caco-2 cell monolayers drug transport model was assigned to study the double transport mechanism of aesculin to explore the absorption of aesculin according as time and drug concentration determined through HPLC and the P_ app was calcalated.RESULTS:In the Caco-2 monolayer model,the transport of aesculin form Apical to Basolateral was similar to the transport form basolateral to apical.CONCLUSION:The main mechanism of the aesculin intestinal absorption in the Caco-2 monolayer model is passive transference.
