Effect of Penehyclidine Hydrochloride on Prevention of Catheter Related Bladder Discomfort after General Anesthesia
- VernacularTitle:盐酸戊乙奎醚对术后导尿管不适的预防效果
- Author:
Xiaomin ZHOU
;
Shaoqiang HUANG
;
Juyun ZHU
- Publication Type:Journal Article
- Keywords:
Penehyclidine;
Atropine;
Catheter related bladder discomfort
- From:Chinese Journal of Pharmacoepidemiology
2007;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy of penehyclidine hydrochloride and atropine in the prevention of catheter related bladder discomfort(CRBD) in patients undergoing gynecology laparoscopic surgery.Method;Eighty ASA classⅠorⅡpatients undergoing elective gynecology laparoscopic surgery were randomly assigned into 2 groups of P and A with 40 cases each.Fifteen minutes before the anesthesia induction,penehyclidine hydrochloride 0.5 mg and atropine 0.25 mg were administered in Group P and Group A,respectively.After the induction of anesthesia,patients were catherized with a 14 Fr Foley's catheter.HR,bladder discomfort,Ramsay Sedative Score(RSS) and side reactions were recorded at 0 h,0.5 h,1 h and 6 h after the end of surgery in the post-anaesthesia care unit(PACU).The severity of bladder discomfort was graded as mild,moderate and severe.Result:The total incidence rate of CRBD in Group P was apparently lower than that in Group A(P0.05).The incidence rate of CRBD of Group P was apparently lower than that in Group A at 6 h after the end of surgery(P0.05).Conclusion:The application of enehyclidine hydrochloride before anesthesia induction provides a better prophylactic effect of CRBD than that of atropine but with a higher incidence rate of dry mouth.
