Effect of Glycyrrhiza Polysaccharide on Immunomodulation in Mice
- VernacularTitle:甘草多糖对小鼠免疫调节作用的影响
- Author:
Fasheng LI
;
Jue ZHAO
;
Xiaofeng CHI
- Publication Type:Journal Article
- Keywords:
Glycyrrhiza uralensis;
polysaccharide;
immunomodulation;
IFN-?;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Glycyrrhiza polysaccharide (GP) on immune function in mice. Methods Polysacchayide was extracted from Glycyrrhiza uralensis by water-extraction-alcohol-precipitation method. Ovalbumin was injected to mice as antigens. The mice were randomly divided into four group:low (50 mg/kg), middle (100 mg/kg), high (200 mg/kg) dosage group of GP and normal control group, 12 mice in each group. Four groups were given GP and NS orally for seven days. After the secondary immunization, the level of antibody and the concentration of serum IFN-? were determined. Results The levels of antibodies and cytokines in middle and low dosage group of GP were all significantly higher than those of control group. Conclusion GP could enhance the immune function of mice.
