Characterization and in vitro permeation of nasal mucosa evaluation of inclusion complex of cholic acid-hydroxypropyl-?-cyclodextrin
- VernacularTitle:胆酸-羟丙基-?-环糊精包合物的物相鉴别及体外鼻黏膜渗透评价
- Author:
Zhetong SU
;
Ming YANG
;
Pinjiang WU
;
Runchun XU
;
Yanan GAO
;
Zheng YANG
- Publication Type:Journal Article
- Keywords:
cholic acid-hydroxypropyl-?-cyclodextrin;
characterization;
test for in vitro permeationof nasal mucosa
- From:
Chinese Traditional and Herbal Drugs
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the permeation of nasal mucosa by preparing the cholic acid-hydroxypropyl-?-cyclodextrin(HP-?-CD) and characterize the inclusion complex.Methods The inclusion complex was characterized by using phase solubility,scanning electron microscope(SEM),Fourier transform-infrared(FT-IR),differential scanning calorimetry(DSC),and superconducting NMR;In an effort to investigate the effect of HP?-CD on cholic acid,the studies of in vitro permeation of nasal mucosa was performed.Results Phase solubility curve was AL type,K=564.30 L/mol,and the characterization de-monstrates the formation of inclusion complex;The permeability coefficients and steady state fluxes through ovine and porcine nasal mucosa were enhanced by the formation of inclusion complex with HP-?-CD about 1.46 and 1.44 times of the uncomplexed cholic acid,respectively.Conclusion The inclusion complex is formed and it could increase the permeability of nasal mucosa by preparing the cholic acid-HP-?-CD.
