The study of Bushen Paidu mixture on expression of integrinsβ1 in mice with renal interstitial fibrosis
10.3760/cma.j.issn.1673-4246.2011.01.009
- VernacularTitle:补肾排毒合剂对肾间质纤维化小鼠整合素β1表达的影响
- Author:
Yuanyuan JIANG
;
Junsheng YU
;
Furong WANG
- Publication Type:Journal Article
- Keywords:
Bushen Mixture;
Renal interstitial fibrosis;
Integrinβ1
- From:
International Journal of Traditional Chinese Medicine
2011;33(1):23-24,27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effects and its possible mechanism ofBushen Paidu Mixture on renal interstitial fibrosis. Methods A total of 60 mice were randomly divided into a normal group,UUO group, Bushen Paidu Mixture group and Lotensin group. Mice models were induced by unilateral ureteral occlusion (UUO). Execute the mice at 7, 14, 21, and 28 days after UUO. The involved kidney were separated and had HE staining. Determine integrinβ1 in kidney tissue through immunohistochemical methods. Results Integrinβ1 tissues had a weak expression in normal kidney. Integrinβ1 expressed higher in UUO group than normal group. The expression of integrinβ1 in Bushen Paidu Mixture group and Lotensin group was lower than the UUO group at every timing point. There is no significant difference between the Bushen Mixture group and Lotensin group in terms of integrinβ1 expression. Conclusion Bushen Paidu Mixture can slow down the process of renal interstitial fibrosis through regulating integrinβ1 expression.
