Enhanced-effect of hypertonic saline,acetic acid and their mixture on hepatic radiofrequency ablation:an experimental study
- VernacularTitle:高渗盐水、冰醋酸及其混合物对肝脏射频消融增效作用的实验研究
- Author:
Baoguo JIANG
;
Ke XU
;
Dongfeng HE
- Publication Type:Journal Article
- Keywords:
hepatic intervention;
experimental study;
radiofrequency ablation;
rabbit,experimental
- From:
Journal of Interventional Radiology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of hypertonic saline,acetic acid and acetic acid-hypertonic saline(AAHS) solution on the ablated volume produced by hepatic radiofrequency ablation(RFA) in rabbits in vivo,and to determine the optimal synergist for radiofrequency ablation.Methods Thirty big-ear white rabbits were equally divided into group A(RFA alone),group B(RFA with 36% NaCl injection),group C(RFA with 50% acetic acid injection),group D(RFA with 50% AAHS injection),group E(50% AAHS injection alone),and group F(36% NaCl injection alone),with five rabbits in each group.Follow-up exam with CT scanning was made.The experimental rabbits were sacrificed by stages.The livers were collected and fixed in 10% formalin.Both the longitudinal and transverse diameter of the necrosis lesion produced by radiofrequency ablation were measured,the results were compared among groups.Results The difference in the lowest impedance value between group A and other groups was statistically significant(P 0.997).The persistent time of group A was significantly shorter than that of both group B and group D(P
