Expres s ion of SDF-1-CXCR4-VEGF-C and the relationship with lymph node metastasis in laryngeal carcinoma
- VernacularTitle:SDF-1/CXCR4与VEGF-C在喉癌中的表达及与淋巴结转移的关系
- Author:
Yuanyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Laryngeal carcinoma;
Stromalcell derived factor-1;
CXC chemokine receptor4;
Vascular endothelial growth factor C
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship of CXCR4,VEGF-C and SDF-1 in human laryngeal carcinoma and discuss the significance of the three indexs in lymph node metastasis.Methods:The expression of CXCR4,VEGF-C and SDF-1 was detected by reverse transcription polymerase chain reaction(RT-PCR)and immuno-histochemical SP in 10 cases of adjacent normal tissue,45 cases of laryngeal carcinoma tissue and cervical lymph node tissue.Results:Not in the mRNA but the level of proteins,The positive rate of the expression of CXCR4 and VEGF-C were 78%,67%and 78%,71%in primary tumor cells,were altogether higher than that in adjacent normal tissue(P
