Protective Effects of Muskone on Rats with Complete Cerebral Ischemia
- VernacularTitle:麝香酮对完全性脑缺血大鼠的保护作用
- Author:
Rong SUN
;
Zuoping ZHANG
;
Wei HUANG
;
Lili LV
;
Haiyong REN
- Publication Type:Journal Article
- Keywords:
Muscone;
Cerebral ischemia/reperfusion injury;
Superoxide dismutase;
Malondialdehyde;
Excitatory amino acid
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of muscone on the blood-brain barrier and neuropathological changes after complete cerebral ischemia/reperfusion of rats.Methods The global cerebral ischemia/reperfusion injury model was established by the four-vessel occlusion(4VO) method,and then the model animals were given high-,middle-and low-dose muscone.Meanwhile,sham-operation group,model group,and positive control group were also set up.The rats neuroethology behavior,and the contents of superoxide dismutase(SOD),malondialdehyde(MDA) and excitatory amino acid(EAA) in ischemic brain tissue were examined.Results Muscone increased SOD content,lowered MDA content,reduced the increase of EAA content caused by ischemia and hypoxia,and inhibited the excitatory neurotoxicity caused by EAA.Conclusion Muscone has obvious protective effect on rats with complete cerebral ischemia/reperfusion injury.
