Therapeutic Effects of Cordyceps Polysaccharide on Chronic Renal Failure Rats Induced by 5/6 Nephrectomy
- VernacularTitle:虫草多糖对大鼠肾脏5/6切除诱发的慢性肾衰的治疗作用
- Author:
Tao CHEN
;
Hongping YIN
;
Xiaobo LV
;
Haitao LI
- Publication Type:Journal Article
- Keywords:
Cordyceps polysaccharide;
Nephrectomy;
Animal models;
Chronic renal failure
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effects of Cordyceps polysaccharide(CP)on chronic reanl failure(CRF) Rats.Methods CRF rat model was estblished by 5/6 nephrectomy.After the modeling,sixty adult SD rats were randomly divided into 6 groups:positive control group(receiving 0.1 mg/kg dexamethasone,im),high-,middle-and low-dose CP groups(gavage of CP at the dose of 160,80 and 40 mg/kg,respectively),sham-operation group(gavage of normal saline at the same volume of CP) and the model group(gavage of normal saline at the same volume of CP).After treatment for 14 days,biochemical indicator,renal function,and renal pathologic changes were observed.Results Compared with the model group,serum urea nitrogen,serum creatinine,urinary protein and urine volume were decreased in the positive control group and CP groups(P
