Pharmacokinetic Study on Transderma Patch of Cyclobuxine D in Rabbits
- VernacularTitle:环维黄杨星D透皮贴剂的药动学研究
- Author:
Xiumei LI
;
Liling ZHOU
;
Yang YU
- Publication Type:Journal Article
- Keywords:
Cyclobuxine D;
Ttransdermal patch;
Precolumn derivatization;
RP-HPLC;
Pharmacokinetics
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the pharmacokinetic parameters and bioavailability of Cyclobuxine D in transdermal patch in Newzealand rabbits by determining concentration-time curve and by comparing with the pharmacokinetics of Cyclobuxine Dinjection and suspension.Methods Precolumn derivatization RP-HPLC was used to detect the concentration of Clovirobuxine D in rabbits plasma at different time,and software 3p87 was used to analyze the pharmacokinetics parameter.Results In contrast to oral delivery,relatively steadily sustained blood concentration with minimal fluctuation and prolonged peak time were presented in the rabbits over a long period after transdermal administration.The absolute bioavailability of Cyclobuxine D was 30.472 %.Conclusion Cyclobuxine D Patch exhibits good controlled-release properties and maintains appropriate blood concentration for a prolonged time.
