Optimization of Reflux Extraction Process of Radix Scutellariae by Central Composite Design/Response Surface Method
- VernacularTitle:星点设计-效应面法优选黄芩提取工艺的研究
- Author:
Rongzhen JIANG
;
Xiaoguang OUYANG
;
Bin HUANG
- Publication Type:Journal Article
- Keywords:
Central Composite Design/Response Surface Method;
Radix Scutellariae;
baicalin
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2008;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To obtain the optimal extraction process of Prunella vulgaris L.Methods With the dependent variables of ethanol concentration,reflux time and solvent fold,and dependent variable of the amount of baicalin,Central Composite Design/Response Surface Method was applied to optimize the reflux extraction process.Predictions were carried out by comparing the observed and predicted values.Results The optimum conditions of extraction process were 45% ethanol,2 hours for reflux,4 fold sovent.Regression coefficients of binomial fitting complex model was 0.9759.Bias between observed values and predicted values was-3.86%.Conclusion The optimum model is simple,precise and highly predictive.
