Study on Techniques of Preparing Baicalin Gelatin Microspheres
- VernacularTitle:黄芩苷明胶微球制备工艺研究
- Author:
Jiajia YAN
;
Anping LI
;
Xianrong LI
- Publication Type:Journal Article
- Keywords:
baicalin;
orthogonal experimental design;
microsphere;
emulsion chemical-cross linking
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2008;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the best techniques of preparing baicalin gelatin microspheres with orthogonal experimental design.Methods Baicalin gelatin microspheres were prepared by emulsion chemical-cross linking method with degradable gelatin as carrier,liquid paraffin as oil phase,Span-80 as emulsifier.The particle size,containing efficiency of microspheres were determined and technique reproducibility was studied.Results Microspheres with good shape,smooth surface and narrow size distribution were prepared.The average diameter of microspheres was 27.47 ?m,the loading amount of medicine was 8.18% and encapsulation efficiency was 70.21%.Conclusion The preparation procedure established was stable and practical.
