Correlation of Serum High-mobility Group Box Protein 1 Level with Defense-Qi-nutrient-blood Syndrome Differentiation and Acute Physiological and Chronic Health Evaluation Ⅱ Score in Sepsis Patients
- VernacularTitle:脓毒症患者高迁移率族蛋白1水平与卫气营血辨证、APACHEⅡ评分的相关性研究
- Author:
Dan ZHANG
;
Zhiyi HU
;
Xinmei WANG
;
Yanli WANG
- Publication Type:Journal Article
- Keywords:
SEPSIS;
DEFENSE-QI-NUTRIENT-BLOOD SYNDROME DIFFERENTIATION;
CORRELATION ANALYSIS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum high-mobility group box protein 1(HMGB1)level in sepsis patients with different syndrome patterns,and to explore the correlation of HMGB1 level with defense-Qi-nutrient-blood syndrome differentiation and Acute Physiological and Chronic Health Evaluation Ⅱ(APACHEⅡ)score.Methods Twenty-four sepsis patients were differentiated as Qi system syndrome(QS group,N=11)and nutrient-blood system syndrome(NB group,N=13).Eight healthy volunteers served as the normal control.APACHEⅡ score was evaluated,serum HMGB1 level was detected by Western blot method,and the correlation of HMGB1 level with defense-Qi-nutrient-blood syndrome differentiation and APACHEⅡ score was analyzed.Results APACHEⅡ score was higher in NB group than that in QS group,the difference being significant(P
