Effect of Shuyusan on Behavior and Concentrations of Neurotransmitters in Chronic Stress Depression Rats
- VernacularTitle:舒郁散对慢性应激抑郁大鼠行为及脑神经递质的影响
- Author:
Liping CHEN
;
Fawei WANG
;
Dongmei DUAN
- Publication Type:Journal Article
- Keywords:
Shuyusan;
depression;
rat behavior;
neurotransmitters
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Shuyusan on the behavior of chronic stress induced depression model rats, as well as concentrations changes of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in cerebral cortex. Method Fifty mice were randomly divided into 5 groups:normal control group, model group, amitriptyline group, and high/low dose prescription group of Shuyusan. Except normal group, the other groups were given the chronic mild unpredicted stress for 21 days. After 21 days different stimulation, open-Field test was used to estimate the behavior of rats, the concentrations of NE, DA and 5-HT were detected with fluorescence spectrometer method. Results Horizontal and vertical motion of the model group was significantly lower than that of the control group (P
