Effects of Compound Ruikangxin Capsula on anxiety-like behavior and relative expression of hippocampal synaptophysin in morphine-withdrawal rats
- VernacularTitle:复方瑞康欣胶囊对吗啡依赖戒断大鼠焦虑行为及海马突触素表达的影响
- Author:
Jifeng HE
;
Gang QIAN
;
Suyuan LUO
;
Mingsong WU
;
Xin LING
;
Xiaodong LI
- Publication Type:Journal Article
- Keywords:
Compound Ruikangxin Capsula(CRC);
morphine withdrawal;
anxiety;
synaptophysin;
hippocampus
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effect of Compound Ruikangxin Capsula(CRC) on anxiety-like symptoms of morphine-withdrawal rats and investigate its mechanism.Methods The elevating doses were applied to validating anxiety-like behavior in SD male rats with sc morphine for 10 d.Treatments with ig administration of CRC(100,200,and 300 mg/kg) and buspirone(15 mg/kg) were performed during 1—3 d morphine withdrawal(twice every day).The plus elevated maze was applied to validating anxiety-like symptom in rats.The expression levels of synaptophysin were detected on hippocampus in groups by immunohistochemitry 72 h after sc morphine.Results As compared with the control group,animals treated with CRC(200 and 300 mg/kg) and buspirone had higher ratio of entry into open arm (P
