Interventional chemoembolization combined with proton radiotherapy for the treatment of hepatocellular carcinoma accompanied with portal cancerous thrombus
- VernacularTitle:化疗栓塞联合质子放射治疗肝癌合并门脉主干癌栓的临床应用
- Author:
Qiang LI
;
Congjun ZENG
;
Ying WANG
- Publication Type:Journal Article
- Keywords:
carcinoma, hepatocellular;
portal cancerous thrombus;
embolization, therapeutic;
proton;
radiotherapy
- From:
Journal of Interventional Radiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the interventional chemoembolization combined with proton radiotherapy in the treatment of hepatocellular carcinoma (HCC) accompanied with cancerous thrombus in the main portal vein. Methods Interventional chemoembolization combined with proton radiotherapy was performed in 46 patients of HCC accompanied with cancerous thrombus in the main portal vein. The proton radiotherapy was broke up into several fractions. The patients were treated with interventional chemoembolization and, alternatively, with proton radiotherapy. The short-term effectiveness and radiation reaction were evaluated. The survival rate was followed up. Results The effective rate was 91.3% . Disappearance of cancerous thrombus in the main portal vein was seen in 45.6% of patients. The liver functions were well restored, with a remarkable reduction in AFP. No acute or delayed radiation-induced hepatic damage or radiation hepatopathy occurred during the course of and after radiotherapy. The survival rate at 1, 6, 12 and 24 months was 100%, 89.1%, 52.2% and 21.4% respectively, with a median survival period of 17.6 months. Conclusion For the patients of HCC accompanied with cancerous thrombus in the main portal vein, interventional chemoembolization combined with proton radiotherapy is an effective, safe and newly-developed therapy.
