Effect of substance P on sensation afferent function of gastrointestinal tract
- VernacularTitle:P物质对胃肠感觉传入功能的影响
- Author:
Lijun DENG
- Publication Type:Journal Article
- Keywords:
Substance P;
Vagus nerve;
Neurokinin-1 receptor;
Gastric distention
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of substance P on sensation afferent of gastrointestinal tract and the corresponding mechanism. Methods:Forty SD rats were divided into 5 groups:control group,low dosage SP group(75 ng/kg),middle dosage SP group(150ng/kg), high dosage SP group(300 ng/kg)and spantideII+SP group.The electrophysiological method was used to record the change of spontaneous and gastric distention-induced afferent discharge of subdiaphragmatic vagus nerve in each group.Results:Intravenous SP (150 ng/kg,300 ng/kg)caused significantly increasing effect on the spontaneous afferent discharge(P
