Changes of LTB4 and 15-HETE in lung of rats with chronic obstructive pulmonary disease and the effects of ipratropium
- VernacularTitle:慢性阻塞性肺疾病大鼠肺组织中LTB4和15-HETE的含量变化及异丙托溴铵对其影响
- Author:
Zhonglian WU
- Publication Type:Journal Article
- Keywords:
Leukotriene B4;
15-hydroxyeicosatetraenoic acid;
Pulmonary disease,Chronic obstructive;
Disease models;
Animal;
Ipratropium
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of leukotriene B4(LTB4)、15-hydroxyeicosatetraenoic acid(15-HETE)in lung of an animal model with chronic obstructive pulmonary disease(COPD),and the effects of ipratropium.Methods:Thirty-six male Wistar rats were randomized into three groups,Group A(normal controls,group B(COPD),group C(smoking+ipratropium),with 12 rats in each group.Group C receiving inhaling ipratropium 0.025%10ml and once a day for 23 days.Pulmonary functions of the rats were assessed, concen-trations of LTB4 15-HETE in lung tissue were measured by RP-HPLC.Results:The lung functions of FEV0.3/FVC%in COPD rats declined obviously(P0.05). Conclusion:Our results suggest that LTB4 and 15-HETE are involved in airway inflammation in COPD.Ipratropium is effective in decreasing the levels of LTB4 and 15-HETE in lung tissue of COPD rats,and attenuating inflammatory changes of airways.
