Study on the mutations of SDHD gene in sporadic pheochromocytoma in Chongqing
- VernacularTitle:散发性嗜铬细胞瘤与SDHD基因突变关系研究
- Author:
Xiulan LI
- Publication Type:Journal Article
- Keywords:
Pheochromocytoma;
Paraganglioma;
Succinate dehydrogenase complex,subunit D;
Mutation
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the association between mutations in the first and second exons of(Succtnate dehydrogenaes complex,subunit D(SDHD)gene and sporadic pheochromocytoma in Chongqing Methods:Polymerase chain reaction combining with single strand conformation polymorphism(PCR-SSCP)was selected to analysis the mutations in the first and second exons of SDHD gene in 32 cases of sporadic pheochromocytoma who were diagnosed by pathology(including 21 cases of pheochromocytoma and 11 cases of extra-adrenal paraganglioma)and 80 cases of the healthy controls.Results:No mutation was found in the first and second exons of SDHD gene in the 32 patients.Conclusion:In our study,we had not found any mutation in the first and second exons of SDHD gene in sporadic pheochromo-cytoma in Chongqing.
