Effect of adjusting blood pressure and blood fat capsule on ET-1 and NOS in early-stage diabetic nephropathy rats
- VernacularTitle:降压调脂胶囊对糖尿病早期肾损害模型大鼠NOS和ET-1表达的影响
- Author:
Yunfang ZHAO
;
Xiaobing LI
;
Ruiqin LI
;
Lili YAN
;
Liyun ZHANG
- Publication Type:Journal Article
- Keywords:
adjusting blood pressure and blood fat capsule;
primary stage diabetes with nephric injure;
model rat
- From:
Chinese Traditional Patent Medicine
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the protecting mechanisms of adjusting blood pressure and blood fat capsule(Radix angelicae sinesis,Rhizoma alismatis,poria,Rhizoma attactylodis macrocephalae,Rhizoma Chuanxiong,Radix Paeoniae alba,semen arecae,Folium perillae) in diabetic nephropathy rats induced by streptozotocin. METHODS: Forty-eight health male Wister rats were randomly divided into normal group,diabetic nephropathy group,adjusting blood pressure and blood fat capsule group and valstatan group.After experiment urine,blood,kidney samples were taken,and immunohistochemistry were performed. RESULTS: 24 hour urinary microalbumin,creatinine clearance,?_2-microglobulin,creatinine clearance ET1 and NOS in kidneys had distinct difference among three gruops. CONCLUSION: The provention and cure of DN ' function of adjusting blood pressure and blood fat capsule bears relationship with inhibition of ET-1,NOS's expression.
