Core formulation optimization of Osmotically Controlled Release Tablets of colchicine
- VernacularTitle:秋水仙碱渗透泵控释片的片芯处方设计
- Author:
Wenping WANG
- Publication Type:Journal Article
- Keywords:
colchicine;
osmotic-pump tablets;
homogenous factor;
orthogonal design
- From:
Chinese Traditional Patent Medicine
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the optimum core formulation and drug release profile of colchicine osmotic pump tablets. METHODS: The key influencing factors and optimum core formulation were studied based on the cumulative drug release rate at different timepoints and homogenous factor(f_2) in combination with the orthoganal design. RESULTS: The drug release profile in vitro was influenced by components of the core tablet,including(amount) of osmogent,solubilizer and adherent.The optimum in vitro drug release profile obeyed the zero-order release model within 1～10 h(r=0.990 2),and drug released at 12h reached up to 85%. CONCLUSION: The colchicine osmotic-pump tablets are attainable by constant speed delivery.
