Effect of Dingchuantang on Expression of NGF in Lung and Thymus of Asthmatic Rats
- VernacularTitle:定喘汤对哮喘大鼠肺组织和胸腺神经生长因子表达的影响
- Author:
Jie LI
;
Canrong WU
;
Lingli CHEN
- Publication Type:Journal Article
- Keywords:
Dingchuantang;
nerve growth factor;
lung;
thymus;
asthma;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Dingchuantang on the expression of NGF in the lung and thymus of asthmatic rats. Methods Thirty two Wistar rats were randomly divided into control group, asthmatic group, Dingchuantang group and Beclomethasone group, 8 rats for each group. Asthmatic model was made except the control group. The change of NGF expression in the lung and thymus were observed by means of immunohistochemistry. Results The expression of NGF in the lung and thymus of asthmatic group was much higher than that of control group and that of Dingchuantang group was much lower than that of asthmatic group. Conclusion Over-expression of NGF might be involved in the pathogenesis of bronchial asthma, and inhibition of NGF expression by Dingchuantang may be one of the mechanisms in the treatment of asthma.
