Effect of Shengmai Capsules on Cadiocyte Apoptosis in Rats with Chronic Congestive Heart Failure
- VernacularTitle:生脉胶囊对慢性心力衰竭大鼠心肌细胞凋亡的影响
- Author:
Yuanjiang DENG
;
Weixiong LIANG
;
Weiying LIU
- Publication Type:Journal Article
- Keywords:
congestive heart failure;
Shengmai capsules;
apoptosis;
Bcl-2;
ventricular remodeling;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the effect of Shengmai capsules on cadiocyte apoptosis with chronic congestive heart failure (CHF) in rats. Methods Seventy five SD female rats were randomly divided into 5 groups:sham-operation group (A), CHF model group (B), CHF model treated by Shengmai capsules group (C), CHF model treated by Captopril group (D), CHF model treated by Shengmai capsule and Captopril group (E). Suprarenal abdominal artery constriction was operated to prepare CHF rat models. After 7 weeks treating respectively, the apoptosis rate of cadiocyte and the content of myocardia Bcl-2 in rats were detected. Results Apoptotic cells ratio of myocardia was higher in group B than in group A (P
