Effect of Baicalin on the Content of Major Amino Acid Transmitters in the Brain of Rat with Experimental Intracerebral Hemorrhage
- VernacularTitle:黄芩苷对脑出血大鼠脑内氨基酸递质含量的影响
- Author:
Qiankun ZHOU
;
Siming YU
;
Ping LIU
- Publication Type:Journal Article
- Keywords:
baicalin;
intracerebral hemorrhage;
glutamate acid;
aspartic acid;
?-aminobutyric acid;
HPLC;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of baicalin on the content of glutamate acid (Glu), aspartic acid (Asp), ?-aminobutyric acid (GABA) in the brain of rat with experimental intracerebral hemorrhage. Methods The intracerebral hemorrhage rat model was induced by collagen enzyme + heparin sodium. The rats were randomly divided into sham group, model group and high, middle, low dose group of baicalin. Rats were treated with the physiological saline and different concentration of baicalin respectively. The brain of each group was taken out three days later and the brain homogenate was prepared. The content of Glu, Asp and GABA was measured with the high performance liquid chromatography (HPLC). Results Compared with the sham group, the levels of Asp were obviously higher (P0.05) in each dose group of baicalin. Compared with the sham group, the contents of Glu were increased obviously (P
