Establishment of alopecia animal model induced by imiquimod in multi-strain mice
- VernacularTitle:咪喹莫特诱导多品系小鼠脱毛动物模型的建立
- Author:
Jia DU
- Publication Type:Journal Article
- Keywords:
Imiquimod;
Toll-likereceptor7;
Alopecia
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To establish a novel alopecia animal model in multi-strain mice.Methods:BARB/c mice,129 mice,C57mice and C3H/HeJ mice were purchased at the age of 6 to 8 weeks. 30 mice of each kind were divided into control and experimental groups randomly. The control group were treated with vehicle alone. The experimental groups were treated with imiquimod cream with cotton swaps for back skin 3 times a week. The existence of TLR7 on skin was examined by immunohistochemistry(IHC). Results:Alopecia lesions were observed in all the mice in experimental group,but mice in control group could not induce by imiquimod. The aggregation of TLR7were observed in hair follicle. Conclusions: Imiquimod can stably induce non-inflammatory alopecia in BARB/c mice,129 mice,C57mice and C3H/HeJ mice by activating TLR7.
