Expression and significance of estrogen receptor ? and ? in endometrium of rats with polycystic ovary syndrome
- VernacularTitle:雌激素受体?、?亚型在多囊卵巢综合征大鼠子宫内膜中的表达及意义
- Author:
Fang AI
- Publication Type:Journal Article
- Keywords:
Estrogenreceptor?;
Estrogenreceptor?;
Polycysticovarysyndrome;
Endometrium
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the expression of estrogen receptor ? and estrogen receptor ? (ER?、ER?) in the endometrium of rats with polycystic ovary syndrome(PCOS). Methods: PCOS model was made by dehydroepiandrosterone(DHEA)and insuline(n=30). The serum hormone levels were examined by radioimmunoassay. The expression of the mRNA and protein of ER? and ER? in endometrium of twogroups were observed by using reverse transcription polymerase chain reaction(RT-PCR)and immunohistochemistry. Results: The expression of protein of ER? in PCOS group in endometrium was significantly higher than those in the control group(P0.05). RT-PCR analysis showed the same expression of ER? mRNA and ER? mRNA in endometrium as immunohistochemistry. Conclusion: ER? in endometrium of PCOS rats is expressed excessively.
