The differential expression of VEGF165b in the renal cell carcinoma and normal renal tissues and its clinical significance
- VernacularTitle:肾细胞癌组织与正常组织中VEGF165b的差异表达及其意义
- Author:
Cuiping JIANG
- Publication Type:Journal Article
- Keywords:
Kidneyneoplasms;
Vascular endothelial growth factor 165b;
Immunohistochemistry;
Reverse transcriptase polymerase chain reaction(RT-PCR)
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Objective:To investigate the differential expression of VEGF165b in the renal cell carcinoma (RCC) and normal renal tissues and its role in the development of RCC. Methods: S-P immunohistochemistry was used to detect the expression of VEGF165b protein in 30 specimens of paraffin-embedded RCC tissues and 29 specimens of paraffin-embedded normal renal tissues. RT-PCR was performed to detect the expression of VEGF165b mRNA in 32 specimens of fresh RCC tissues and 30 specimens of fresh normal renal tissues. Results: Among 29 of normal renal tissues,28 specimens had positive expression of VEGF165b protein,with the positive rate of 96.55%(28/29) that was significantly higher than 20.00%(6/30)in RCC tissues(P
