Evaluation of the curative effect of neoadjuvant chemotherapy for advanced carcinoma in the digestive tracts
- VernacularTitle:新辅助化疗在进展期消化道肿瘤中的疗效评估
- Author:
Leiyuan SHUAI
- Publication Type:Journal Article
- Keywords:
Carcinomainthedigestivetracts;
Neoadjuvantchemotherapy;
Surgery;
Curativeeffect
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the therapeutic effect of neoadjuvent chemotherapy for grade Ⅲ and Ⅳ carcinoma in the digestive tracts,Methods: A total of 30 cases of carcinoma in the digestive tracts were collected;including 9 cases in grade Ⅲa,13 cases in grade Ⅲb,and 8 cases in grade Ⅳ admitted to our hospital.Through gastroscope、enteroscope and CT investigation after admission,20 cases had been determined as advanced carcinoma in the digestive tracts before operation.Then the cases underwent chemotherapy twice,were rechecked by CT,and finally accepted operation treatment.The changes of the cancer volume,labelling micovessel index CD105 and the content of the inhibitory protein of apoptosis survivin from excisional tumor tissue were compared after operation. Results: 1.The change of tumorvolumebeforeandafterchemotherapyshowedstatisticalsignificance(P0.05)between intervenient chemotherapy group and systematical chemotherapy group. None died from operation. Conclusion: Surgical therapy after neoadjuvent chemotherapy for advanced cancer in the digestive tracts can improve the rate of exairesis and therapic effect.
