Effect of Scutellaria Baicalensis Stem-leaf Total Flavonoids on Lipid Metabolism in Hyperlipidemia Rats
- VernacularTitle:黄芩茎叶总黄酮对高脂血症大鼠脂代谢的影响
- Author:
Xiaoxia ZHOU
;
Cuilan YOU
;
Peiqing SU
;
Wangdi ZHU
- Publication Type:Journal Article
- Keywords:
Scutellaria baicalensis stem-leaf total flavonoids;
Hyperlipidemia;
Lipid metabolism;
Fecal bile acids
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Scutellaria baicalensis stem-leaf total flavonoids(SSTF)on lipid metabolism in hyperlipidemia rats.Methods On the basis of establishing hyperlipidemia rat model,blood and liver lipids,lipid metabolic enzyme,and the amount of fecal bile acids were investigated after feeding of fatty emulsion for 30 days.Results Compared to the model group,SSTF significantly reduced the serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),and increased high density lipoprotein cholesterol(HDL-C),increased the activity of lecithin cholesterol acyltransferase(LCAT).SSTF also showed the effect on decreasing liver TC,TG and increasing the amount of fecal bile acids.Conclusion SSTF have an effect on decreasing lipid metabolism in hyperlipidemia rats,and the possible mechanism is associated to the increase of LCAT activity and fecal bile acids excretion.
