Antithrombotic Effect of Polysaccharide Extracted from Thallus Laminariae on Rats with Endothelial Injury
- VernacularTitle:海带多糖对内皮损伤大鼠血栓形成的影响
- Author:
Liping WANG
;
Menghua CHEN
;
Lu XIE
;
Shen ZHAO
;
Huiqin ZHANG
- Publication Type:Journal Article
- Keywords:
Thallus Laminariae;
Polysaccharide;
Thrombus;
Adrenaline;
Endotoxin
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antithrombotic effect of polysaccharide extracted from Thallus Laminariae(PTP) on rats with endothelial injury.Methods Two kinds of endothelial injured rat models were established by injecting adrenaline and endotoxin.The wet weight of thrombus was evaluated by artery-vein loop method,the starting time of thrombus formation and the speed of blood flow were observed by mesentery microcirculation.Results In adrenaline-induced injury rats,the wet weight of thrombus was obviously decreased in high-dose PTP group and aspirin group compared with the model group.In endotoxin-induced injury rats,the starting time of thrombus formation was longer and the one-hour blood flow speed was faster in all TP groups and aspirin group than those in the model group.Conclusion PTP exerts the antithrombotic effect on rats with endothelial injury.
