Protective Effect of Danhong Injection on Ischemia-reperfusion Injury in Rats After Kidney Transplantation
- VernacularTitle:丹红注射液对大鼠移植肾缺血再灌注损伤的保护作用
- Author:
Kang XIA
;
Xiaohou WU
;
Jiabing LI
- Publication Type:Journal Article
- Keywords:
Renal ischemia-reperfusion injury;
Danhong Injection;
Bcl-2;
Bax;
Bcl-2/Bax;
Apoptosis
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of Danhong Injection(DI) on rats ischemia-reperfusion(I/R) injury after kidney transplantation.Methods Ten normal SD rats were allocated into the sham-operation group,and they were only been anesthetized and exposed kidneys for 45 minutes.The allogeneic male SD rats model of kidney transplantation were established.The qualified rats were divided into 3 groups(10 in each group)at random:I/R model group,DI pretreatment group,and DI treatment group.B1ood urea nitrogen(Bun) and creatinine(Cr) levels in each group were determined at the 24th hour after operation.The expression of Bax and Bcl-2 in kidney were quantitatively detected by immunohistochemistry.Apoptotic index was measured by TUNEL method.Results Compared with the sham-operation group,the apoptosis rate(P
