Experiment Study on In-vitro Anti-rotavirus Effect of Zhixie Tuire Tablets
- VernacularTitle:止泻退热片体外抗轮状病毒的作用
- Author:
Mengmeng YANG
;
Jiabo LUO
;
Wen CHEN
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
Zhixie Tuire Tablets;
In vitro;
Rotavirus
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the pharmacological effect of Zhixie Tuire Tablets(ZTT) on human rotavirus RV709 in host cells in vitro.Methods By improved methods of methyl thiazolyl tetrazolium colorimetry assay(MTT) and cytopathic effect(CPE),the anti-rotavirus effect of ZTT on RV709 was evaluated.Results The half toxic concentration(TC50) of ZTT for MA104 was 0.49699 mg/mL.ZTT neither can directly kill human rotavirus,nor prevent human rotavirus from invasion of host cells.The halft inhibitory concentration of ZTT was 0.00519 mg/mL for RV709.Conclusion In-vitro anti-rotavirus mechanism of ZTT is related to the inhibition of the biological synthesis of rotavirus in host cells.
