Effect of Hirudo Micropowder on ICAM,VCAM and PDGF in Rats with Cerebral Ischemia-Reperfusion Injury
- VernacularTitle:水蛭微粉对脑缺血再灌注损伤大鼠ICAM、VCAM、PDGF的影响
- Author:
Keming LI
;
Jibiao WU
;
Zaiyun SUI
;
Aijie WANG
- Publication Type:Journal Article
- Keywords:
Hirudo;
Micropowder;
Cerebral ischemia;
Reperfusion Injury;
Rats
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hirudo micropowder on inflammatory factors in rats with cerebral ischemia-reperfusion injury.Methods Rats were randomly divided into sham-operation group,model group,coarse powder hirudo group,high-,middle-and low-dose micropowder hirudo groups.The corresponding drugs were given to the rats for 10 days by intragastric administration.Then middle cerebral artery occlusion(MCAO) model was made by suture method.The changes of inflammatory factors were observed.Results The level of intercellular adhesion molecule 1(ICAM-1) in high-dose micropowder hirudo group was lower than that in coarse powder hirudo group,and the level of platelet-derived growth factor(PDGF) in middle-and high-dose micropowder hirudo groups was also lower than that in coarse powder hirudo group obviously(P
