Preparation and phase solubility of inclusion complex of cholic acid-hydroxypropyl-?-cyclodextrin
- VernacularTitle:胆酸-羟丙基-?-环糊精包合物的制备工艺及相溶解度研究
- Author:
Zhetong SU
;
Ming YANG
;
Pinjiang WU
;
Runchun XU
;
Yanan GAO
;
Shuiping OU
- Publication Type:Journal Article
- Keywords:
cholic acid-hydroxypropyl-?-cyclodextrin;
HPLC;
preparation;
phase solubility
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To optimize the preparation of cholic acid-hydroxypropy-?-cyclodextrin inclusion complex,and its phase solubility analysis. METHODS: Orthogonal test,including molar ratio,inclusion temperature,mixing time and liquid dropping rate of cholic acid-HP-?-CD,was adopted to screen the optimal preparation,based on the inclusion efficiency by HPLC method.The solubilization effect was evaluated by using phase solubility.(RESULTS): The optimal preparation consisted of the molar ratio of cholic acid-HP-?-CD was 1∶3,60 ℃ inclusion temperature,60 min mixing time,1.6 mL/min liquid dropping rate;A_L type of phase solubility curve,K=564.30 L/mol,and 11.81 times solubilization. CONCLUSION: The optimal preparation is stable,reasonable and practicable with the encapsulation efficiency of 97.1%.Inclusing cholic acid with HP-?-CD is feasible,and the solubilization effect is significant.
