Pharmacokinetics of Paeonia lacliflora and Glycyrrhiza uralensis Compound
- VernacularTitle:芍药甘草复方配伍药动学研究
- Author:
Lan SHEN
;
Liang ZHANG
;
Yi FENG
;
Desheng XU
;
Xiao LIN
- Publication Type:Journal Article
- Keywords:
Paeonia lacliflora and Glycyrrhiza uralensis;
pharmacokinetics;
paeoniflorin;
glycyrrhizic acid;
liquorice flavones;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study compatibility rationality of combination of Paeonia lacliflora and Glycyrrhiza uralensis. METHODS: The effective combination of paeoniflorin(44% purity),glycyrrhizic acid(50% purity) and liquorice flavones(52% purity),glycyrrhizic acid(50% purity) and liquorice flavones(52% purity) were respectively administered to rats.Pharmacokinetic change of these constituents in rat blood was studied. RESULTS: The pharmacokinetic parameters of these constituents in rat blood showed that the increases in AUC and C_(max) of effective combination group were more than that of glycyrrhizic acid group or that of liquorice flavones group.T_(max) of the former was extended with respect to the latters.Clearance of effective combination markedly slowed down. CONCLUSION: The effective combination of paeonia lacliflora and Glycyrrhiza uralensis have the advantage of either Paeonia lacliflora or Glycyrrhiza uralensis.
