Association of SNP276 in adiponectin gene with complicating different component numbers of metabolic syndrome in population with impaired glucose regulation
10.3760/cma.j.issn.1008-1372.2012.01.005
- VernacularTitle:糖调节受损脂联素基因SNP276多态性与代谢综合征异常组分数量的关系
- Author:
Xuemei FAN
;
Guangxia XI
;
Baozhen ZHAO
;
Xiaoli LI
;
Ye LIU
;
Fang GAO
;
Bing TIAN
- Publication Type:Journal Article
- Keywords:
Glucose intolerance/CO/GE;
Blood glucose/ME;
Adiponectin/GE;
Metabolic syndrome X/CO/GE;
Polymorphism,single nucleotide
- From:
Journal of Chinese Physician
2012;14(1):13-15,19
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the association of SNP276 in adiponectin gene with impaired glucose regulation (IGR) complicating with the different component numbers of metabolism syndrome (MS) in population of IGR in Han people of Shanxi region.MethodsThe study population consisted of 256 subjects with IGR which was composed of 123 subjects with component numbers of MS ＜2 (IGRA) and 133subjects with component numbers of MS≥2 (IGRB),and 128 subjects with normal healthy (Normal) who were Chinese Hans residents and in Shanxi province.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was applied to test the adiponectin SNP276G/T polymorphism.ResultsThe distributions of genotypes and alleles of SNP276 both displayed significant difference among the three groups ( x2 =16.893,P =0.002 ; x2 =18.149,P =0.000).In the IGRA,the SNP276 non-TT ( GT + GG) genotype was no difference which increased risk of complicating with the different component numbers of MS( P =0.781,P =0.809).In IGRB,the SNP276 non-TT ( GT + GG) genotype was associated with increased risk of complicating with the different component numbers of MS,and after age and sex-adjusted,there was significant difference ( P =0.007,P =0.007).ConclusionsSNP276 in APM1 increased the risk of complicating with the components of MS in population with impaired glucose regulation in Han people of Shanxi region.
