In-vivo Anti-virus Effect of Baicalein on Influenza A Virus
- VernacularTitle:黄芩素体内抗甲型流感病毒作用的研究
- Author:
Xiuhua WU
;
Ni LIU
;
Li YANG
;
Hairong SHEN
- Publication Type:Journal Article
- Keywords:
BAICALEIN/pharmacology;
VIRAL PNEUMONIA/TCD therapy;
INFLUENZA A VIRUS;
LUNG/pathology;
DISEASE MODELS,ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-virus effect of baicalein on influenza A virus in vivo.Methods NIH mice were randomized into the normal control group,model group,virazole group(at the dose of 0.07g?kg-1?d-1),high-,middle-and low-dose baicalein groups(100,10 and 1 ?g?kg-1?d-1 respectively).Mice infected models were induced by intranasal drip of influenza A virus strain FM1.The lung index,inhibitory rate of lung index,survival rate and death prevention rate as well as the pathological changes of lungs were observed.Results Compared with the normal control group,the lung index and survival rate were decreased(P
