Effects of Pingxian Powder on N-methyl-D-aspartate Rreceptor1 and ?-aminobutyric Acid-A Receptor ?_1 in Central Nervous System of Pentylenetetrazol-induced Epileptic Rats
- VernacularTitle:平痫冲剂对戊四唑致痫大鼠海马氨基酸类神经递质受体的影响
- Author:
Rong TIAN
;
Shiqing ZHANG
;
Zhenggang SHI
- Publication Type:Journal Article
- Keywords:
epilepsy;
Pingxian Powder;
NMDAR;
GABA-AR;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Though immunohistochemical study on the effects of Pingxian Powder on N-methyl-D-aspartate receptor1 (NMDAR1) and ?-aminobutyric acid-A receptor ?1 (GABA-AR ? 1 ) in central nervous system of pentylenetetrazol-induced epileptic rats, to explore its possible antiepileptic mechanism. Methods Sixty wistar rats were divided into control group (A), model group (B), phenobarbital group (C) and Pingxian Powder small (D), middle (E), Large (F) dosage group. Pentylenetetrazole (PTZ) was injected into abdomen of rat to reconstruct epileptic kindling model. The total number, percentage of positive area and integral optical density of NMDAR1 and GABA-AR ? 1 of immunoreactive cells in hippocampus CA 1 , CA 3 were studied by the immunohistochemical method and image analyzing system. Results The total number, percentage of positive area and integral optical density of NMDAR1 of immunoreactive cells in hippocampus formation of Group B were more than Group A (P
