Effects of Compounded Sour Medicinal Herbs on Deposition of AGEs and Gene Expression of RAGE in the Myocardial Tissue in Diabetic Rats
- VernacularTitle:酸味中药复方对糖尿病大鼠心肌组织晚期糖化终产物形成及其受体基因表达的影响
- Author:
Dezeng ZHU
;
Guixiang YIN
;
Yuli CAO
- Publication Type:Journal Article
- Keywords:
type 2 diabetic mellitus;
myocardial tissue;
AGEs;
RAGE;
gene expression;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible mechanism of Compounded Sour Medicinal Herbs (CSMH) in preventing and amelioration type 2 diabetic mellitus (T2DM) rats chronic complication, by analyzing the effects of CSMH on the deposition of advanced glycation end products (AGEs) and gene expression of their receptor myocardial tissue in T2DM rats. Methods The rats were injected with streptozotocin (STZ) through peritoneum, and fed with high-fat and high-caloric diets to induce T2DM animal models. Then the rats were randomly divided into three groups:untreated group (model group), AG treated group and CSMH treated group. The deposition of AGEs and gene expression of RAGE in the myocardial tissue of T2DM rats were detected separately by fluorescence and real time PCR method. Results The deposition of AGEs and gene expression of their receptor in myocardial tissue in control group were lower than that of T2DM rats (P
