Pharmacodynamic Research of Tongmai Oral Liquid on Preventing and CuringⅡPeriod Diabetic Nephropathy
- VernacularTitle:通脉口服液防治Ⅱ期糖尿病肾病的药效学研究
- Author:
Zaikang ZHANG
;
Nizhi YANG
;
Jingwen SU
- Publication Type:Journal Article
- Keywords:
Ⅱ period diabetic nephropathy;
Tongmai oral liquid;
pharmacodynamics;
animal model
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Tongmai oral liquid on the early diabetic nephropathy. Methods Diabetic nephropathy rats were induced by excision of the right kidney and a single intraperitoneal injection of streptozotocin (STZ). Forty male Wistar rats were divided randomly into 3 groups:Tongmai group, nephrotic model group, and normal group. At the end of the 8th week, the rats general states and some parameters such as kidney hypertrophy index, 24 h urine volume, blood glucose, 24 h urinary microalbumin (24 h UMA), renal function [serum creatinine (Cr), blood urea nitrogen (BUN)], serum lipid, and the change of nephritic pathologic lesion were measured. Result Compared with the model group, general states in Tongmai group were improved, there was a considerable increase on body weight (P
