Effects of Chinese Medicine Compound on Bone Loss of Weightlessness Rats Simulated by Suspension
- VernacularTitle:中药复方对模拟失重大鼠骨丢失的影响
- Author:
Haiying TONG
;
Sumin HU
;
Xuemin GAO
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
simulated weightlessness;
BMD;
bone biomechanics;
bone histomorphometry
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Chinese medicine compound on bone density, biomechanics, histomorphometry of weightlessness rats simulated by tail suspension. Methods Fifty Wistar rats were randomly divided into 5 groups with 10 rats each group:control group, model group, and low dose, medium dose and high dose Chinese medicine compound treated suspension group, the experiment period was 21 days. BMD of femur and lumbar vertebrae were detected by dual energy X-ray absorptiometry. The femoral biomechanics parameters and anti-compress ability of lumbar vertebrae were measured by three-point assay and compress test respectively. The quantitative structures of non- decalcified bone tissue sections were analyzed by histomorphometry. Result Compared with control group, BMD of femur and lumbar of model group decreased remarkably (P
