Effect of Danlong Xingnao Tablet on the Expression of TNF-? and Apoptosis after Focal Cerebral Ischemia Reperfusion in Rat Hippocampus
- VernacularTitle:丹龙醒脑片对大鼠局灶性脑缺血再灌注后海马区肿瘤坏死因子?表达和细胞凋亡的影响
- Author:
Qian HE
;
Xiaoqin ZHOU
;
Hua LI
- Publication Type:Journal Article
- Keywords:
cerebral ischemia reperfusion;
Danlong Xingnao Tablet;
apoptosis;
TNF-?;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Danlong Xingnao Tablet on neuronal apoptosis and expression of TNF-? after focal cerebral ischemia reperfusion in rat hippocampus. Methods The model of middle cerebral arteries occlusion (MCAO) were performed with intraluminal filament blockade. By using in situ terminal deoxynucleotidyl transferase-mediated dUTP-biotor nick end labeling (TUNEL) and immunohistochemistry staining, the number of apoptotic cells and TNF-? positive cells were detected in the sham-operated group, the ischemia reperfusion group, Danlong Xingnao Tablet group and nimodipine group after the middle cerebral arteries of SD rats occluded for 1 h and reperfused for 24 h.Results Compared with the sham operation group, the number of apoptotic cells and TNF-? positive cells of the model group increased significantly (P
