Analysis on migrating constituents absorbed into blood of mice after ig administration of Resina Draconis
- VernacularTitle:龙血竭小鼠灌胃给药后血中移行成分的分析
- Author:
Xu CHEN
;
Kelan YONG
;
Jingci L
;
Tianbao ZHANG
- Publication Type:Journal Article
- Keywords:
Resina Draconis;
serum pharmacochemistry;
HPLC;
LC-MS/MS
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Serum pharmacochemistry was performed to screen the bioactive constituents of Resina Draconis.Methods Based on HPLC fingerprints of Resina Draconis,the migrating constituents absorbed into blood were determined by comparing the HPLC fingerprints of extraction of Resina Draconis(ERB),herb serum sample,and control serum sample,and with the help of LC-MS/MS.Results Six compounds absorbed into blood were detected,five of them were original in form which were 3,4′-dihydroxy-5-methoxystilbene,cochinchinenin B,4′-hydroxy-4,2′-dimethoxy-dihydrochalcone(a new compound),cochinchinenin A,and loureirin B,respectively.The other might be the original constituent or the metabolite.Conclusion The six constituents absorbed into blood are possible bioactive components of Resina Draconis in vivo.Further research will help clarify the bioactive constituents and mechanisms of Resina Draconis.
