Preparation of total glucosides in paeony sustained-release pellets by fluidized bed coating method
- VernacularTitle:流化床包衣法制备芍药总苷缓释微丸的研究
- Author:
Lihua CHEN
;
Desheng XU
;
Yi FENG
;
Yanlong HONG
;
Yihan WANG
- Publication Type:Journal Article
- Keywords:
totel glucosides of paeony(TGP) sustained-release pellets;
Eudragit RS 100;
sustained-release pellets;
dissolution
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare totel glucosides in paeony(TGP) pellets by extrusion-spheronization and to optimize the formulation of TGP sustained-release pellets coated with Eudragit RS 100.Methods The TGP sustained-release pellets were prepared by mini Glatt fluidized bed coating method.The factors to influence the drug release behaviors and their properties were evaluated.Results The optimal TGP sustained-release pellet was shown significant sustained-releasing at the loading weight of copolymers of 6% and the plasticizer concentration of 10%.And the curves of cumulative drug release were fit for Peppas and Higuchi equation.Conclusion The pellets showed an obviously sustained-release effect.
