The experimental study of effects of fu fang tang yang you on healing and reducing the proliferation scars of deep partial thinkness burn in rats
- VernacularTitle:复方烫疡油促进深Ⅱ?烫伤创面愈合、减少瘢痕形成的实验研究
- Author:
Cong LUO
- Publication Type:Journal Article
- Keywords:
Burn;
Wound healing;
Scar;
Fu Fang Tang Yang You
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects and the therapeutic mechanism of Fu Fang Tang Yang of You(FTY)on wound healing and reducing the proliferation scar of deep partial thinkness nurn in rats.Method 120 kun-ming rats were employed as the model.Deep partial thinkness burn wound(s3 cm2 per wound)were made on the back of each rat by 108℃steam.The wound rats were divided into five groups.Four groups underwen(tgroupA,B,C,D)local treatment with FTY,rhEGF,Sulfadiazine silvercream and Vegetable oil,respectively.The control group E was localy treatment with applied the normal saline.Each wound area was calculated by dry/wet weight at 8,24,48,72 hafterinjury.Histological examination:Determination of TGF-?1,typeofcollagenⅠ,Ⅲwith immunohistochemistry.Expression of MMP-1,TIMP-1 were testd by in situ hybridiz-ation and image analgsis at 3,7,14 past-burn days.The apoptosis index was exmined by TUNEL technique.Results:Treatment with FTY could protect the remains of cells and tissues in wound,alleviate inflammatory response,decrease the level of tissues edema,reduce the formation of proliferation scars and accelerate the process of wound healing.Conclusion.FTY could promote the wound healing of deep partial thinkness burn with less scar formation.
