Study of TACE in the mechanism of hyperalgesia derived by auto-transplantation of nucleus pulposus to DRGs
- VernacularTitle:TACE在自体髓核移植背根节致根性神经痛中的作用机制研究
- Author:
Xing CAO
- Publication Type:Journal Article
- Keywords:
Nucleus pulpusus;
Sciatica;
Tumor necrosis factor alpha(TNF-?);
Tumor necrosis factor-?converting enzyme;
Ganglion
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of TACE in the mechanism of sciatica due to disc herniation.Methods:Autologous nucleus pulposus was applied to the peripheral of the L4 and L5 nerve roots and DRGs to construst animal model.Then Von Frey filaments and a thermal testing device(RTX-1 type)were used to quantify behavior test.Immunocytochemistry and RT-PCR were used to detect the ex-pression changes of TNF-?and TACE to analyze their correlation with the nerve behavior change.Results:The mRNA expression of TNF-?and TACE increased significantly(P
