Mechanism of apoptosis in hippocampus of the rats with disorder of cortical developments
- VernacularTitle:皮质发育障碍模型鼠海马区神经元凋亡机制的研究
- Author:
Hua HUANG
- Publication Type:Journal Article
- Keywords:
Disorder of cortical developments;
Cell apoptosis;
Bax;
Bcl-2;
Epilepsy
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the mechanism of apoptosis in hippocampus of the rats with disorder of cortical developments.Methods:The Rats with disorder of cortical developments were established by carmustine(BUCN).AT P0,P15,P30,P45,P60,the number of apoptosis cell and expression of Bax and Bcl-2 in hippocampus were detected by TUNEL,immunohistochemistry method and RT-PCR;then the detected outcomes were analyzed by computer micrograph analysis system in control group and model group.Results:At P15,P30,P45,P60,the numbers of apoptosis,Bax,Bcl-2 masculine cell and bcl-2 MRNA,bax MRNA in hippocampus in the model group were more than those in the control group.The ratio of Bax/Bcl-2 in model group was significantly higher than those in the control group(P
